The aim of the project is to modernise the equipment of the Czech Infrastructure for Integrative Structural Biology (CIISB) in CEITEC and BIOCEV research centres and support its use in research focused on interactions of biomolecules relevant for human health and disease treatment. Implementation of the project will strengthen CIISB services offered in open access mode, thereby contributing to the development of the European infrastructure INSTRUCT and make available the latest technologies and instrumentation to the Czech biomedical research community. a.