The project focuses on clinical research and development of medicinal products for advanced therapy (ATMP) and personalised medicine in the field of rare diseases (VO) in the paediatric population. The project has a major impact on the treatment of the VO. Its aim is to develop innovative ATMP for treatment of VO, which is to be prepared for the clinical trial phase. The results of the research will also bring new methodological procedures in the personalised treatment of paediatric oncological diseases based on monitoring of targeted anticancer medicines. a.