The main objective of the project is to understand the exact functioning of certain biological/neuronal structures. In order to achieve this main objective, we propose three derived objectives: 1. Obtaining new computational models for accurate modeling of neurons (WP1&2); 2. Developing a package of programs to simulate architectural structures that integrate new computational models, allowing verification of their correctness; the simulations will reproduce the results of state-of-the-art experimental measurements (WP3); 3. Design, simulation and testing of circuits incorporating new computational models, verifying (again) that they function properly, and providing the semiconductor industry with potential solutions for technologies over the next 10-20 years (WP4). The fundamental motivation of the project is given by the biggest challenges of the semiconductor industry, namely: (I) the reliability of the circuits, and (ii) the power consumed by them. To meet these two challenges, the project aims (through its objectives) to understand the (neuronal) biological model and to use it in the design of the integrated circuits of the future, because: 1. The reliability of biological structures (which operate for decades) is much higher than that of current integrated circuits (which fail after just a few years); 2. The power consumed by biological structures to perform calculations of impressive complexity (processing 200 million pixels) requires microwatts and is incomparably smaller than any silicon-based structure (which requires milli-watts). Through the proposed objectives, the project theme falls within the high-risk high-risk project class, which is currently a priority at European level. Apart from dedicated programmes to financially support such projects at European level (as European Research Council, http://erc.europa.eu/), recently (15 June 2015), Carlos Moedas, European Commissioner for Research Science and Innovation, said that: “I would first like to highlight that today’s amendments represent a move towards a diversification of how we finance research and innovation in Europe: a move towards investment in high-risk, high return projects" (see https://ec.europa.eu/commission/2014-2019/moedas/announcements/new-financing-opportunities-innovative-enterprises-and-investors_en).