The main objective of the project is to stabilise the quality research teams of the Biomedical Centre SAS in the knowledge field of Pharmacy and Medical Sciences and to implement the activity of independent research and development in the period up to 31. 12. 2019 with relevant outputs. The project focuses on research of selected mechanisms, molecular traits and preclinical models of human diseases in the field of oncology, neurobiology and endocrinology. These are prospective research topics complementary to the supporting projects of BMC SAV, which, in terms of staffing capacity, were not financed from any competition scheme, but solely from their own institutional salary resources. Key scientific personalities as well as young scientists are involved in this research, motivating them to acquire new knowledge relevant to preclinical studies and potentially applicable in clinical practice. Each theme consists of separate sub-activities (PA) of the main activity, which will be implemented both during and after the implementation of the project: PA1: proteomic analysis of molecular pathways induced by brain and spinal cord damage in the body of the rat; PA2: development of methodologies for culture and processing of cell lines producing bioactive substances, purification procedures and stability tests of substances for molecular characterisation and preclinical testing; PA3: molecular characteristics of the mouse variant of the tumor biomarker for the purpose of in vivo preclinical studies; PA4: research on the impact of natural selenium compounds and their synthetic derivatives on the process of feroptose in tumour cells; PA5: personalisation of bioinformatic laboratory BMC SAV for the purpose of analysing data from whole-exom sequencing and with the reintegration of top researchers after returning from abroad. Places of implementation: in Košice and Šarišské Michaľany, within 49 % flexibility in Bratislava. Measurable indicators: existing researchers – value of 6.4 FTE, 2 reintegrated Slovak researchers, 2 publications, 1 supported research institution.
