The National Infrastructure Centre for the Study and Sustainable Exploitation of Marine Biological Resources (CMBR) is a distributed infrastructure of the National Road Map for Research Infrastructures (2014). The CMBR consolidates the network of the scientific community that produces high-level research in the field of access for living organisms, through a number of original platforms, equipment, software and data. The CMBR’s vision is long-term cooperation to create development strategies, best practices and standards related to the sustainable use of marine biological resources to meet the needs of its users, promote marine research, and support the blue bio-economy at regional and national level. CMBR aims at the construction and operation of services that support both basic and applied research and the availability of facilities, equipment and expertise to users from the academic and research field, industry and the state. The main objective of Infrastructure is also the exploitation, by the productive-industrial sector, of the research results resulting from its operation and its actions, in order to promote the priorities of Smart Specialisation and Blue Growth. The development of Blue Biotechnology, with the isolation and production of bioactive substances (medicines, chemicals for a range of applications) from marine organisms is central. The CMBR services offer access to national marine and coastal ecosystems, biodiversity, marine model species, crop collections, technological platforms, approaches and applications of biodiversity bass and IT, as well as laboratory training facilities and services. The Institute of Marine Biology, Biotechnology and Aquaculture (ITHABYK) of the Hellenic Centre for Marine Research (ELKETHE) coordinates the construction and operation of the CMBR Infrastructure. The consortium consists of nine research and academic partners from all over the country, focusing its activities in Heraklion, Crete.