The inclusion of these teams in the Microsurgery Unit would involve the addition of new services to our Center, as well as collaboration with other National Centers such as Gregorio Marañón, Ramón y Cajal Hospitals and Peace and International Hospitals such as Columbia University. These teams allow us a great advance to be able to propose new lines of research in reconstructive surgery, mainly in the application of exosomes derived from mesenchymal stem cells to reduce the failure of microsurgical flaps that suffer ischemia-reperfusion and the supramicrosurgery of lymphedema. All this to develop a therapy adjuvant to the microsurgical reconstructions suffered by flaps practiced in reconstructive surgery and to provide solutions to a variety of skin and myocutaneous defects that are generated by trauma, burns, congenital disorders or neoplasms, which are not yet provided optimal treatment. _x000D_ national research would be placed in a privileged position in this area of knowledge, since at present, there are not many research groups internationally working in the field of plastic and reconstructive surgery with mesenchymal stem cells from adipose tissue and we would be the first group worldwide.