BREAST CANCER RANKS FIRST AMONG CANCERS THAT AFFECT WOMEN. EARLY DIAGNOSIS INFLUENCES THE EVOLUTION OF PATIENTS SO THAT EARLY DETECTION PLAYS AN IMPORTANT ROLE IN BREAST CANCER. DESPITE THE ESTABLISHMENT OF PROGRAMS BASED SCREENING MAMMOGRAMS, RECENT STUDIES QUESTION THEIR CAPACITY WHEN REDUCING MORTALITY. THE OBJECTIVE OF THIS PROJECT IS TO TRACK DIRECTED WOMEN STRATIFIED AS HIGH AND LOW RISK IN WHICH THE GENETIC SIGNATURE (MICRORNAS) PREVIOUSLY IDENTIFIED IN WOMEN WITH BREAST CANCER DIAGNOSIS, IN THOSE SELECTED AS HIGH RISK WOMEN IN BE ANALYZED GENERAL POPULATION AFTER APPLYING THE ALGORITHM BRECAN RISK © TO ESTABLISH WHETHER MICRORNAS CIRCULATING MARKERS CAN BE APPLIED AS MARKERS FOR EARLY DETECTION. PARALLEL WILL ALSO WORK ON A RETROSPECTIVE ANALYSIS OF 500 HEALTHY WOMEN STUDIED 10 YEARS EARLIER IN MAMMOGRAPHIC SCREENING, WHICH WILL APPLY BRECAN RISK AND PHENOTYPIC DATA WILL BE COLLECTED AT THE TIME, TO COMPLETE THE CLINICAL VALIDATION OF RISK ALGORITHM BRECAN RISK ©. THE CORRELATI