Ischemic stroke (synonymous cerebral infarction) affects 137 out of 100,000 inhabitants each year, and around 30 % of those affected die within a year. As a result, the brain infarction is of great socio-economic importance, which continues to increase due to the increasing probability of stroke and demographic development in Germany as age increases. This results in high demands on the medical care system in Germany. The project pursues the hypothesis in a hospital-oriented research approach that pathological changes of cell structure stabilising elements play a decisive role in the process of the formation of permanent tissue damage after brain infarction and are therefore considered as the target structure of previously unused therapy approaches. In the animal model, therefore, structural, functional and mechanical properties of intracellular and extracellular structural stabilising elements in close relation to the blood-brain barrier are to be examined and verified under the conditions of the brain attack. The focus is on structural stabilising elements that are particularly sensitive to ischaemic stimuli and are therefore eligible for pharmacological modulation. This approach should allow a reduction in brain infarction and functional impairment by applying specific pharmaceuticals in the perspective.