The current effort to prevent type 2 diabetes (DT2) in the adult obese population is often too late, costly, and ineffective. A real prevention of DT2 and vascular complications would be to act from childhood. We have demonstrated that loss of integrity of elastic fibers, responsible for vascular resilience, contributes to the development of DT2. Elastin, a major compound of these fibres, is synthesised until puberty and its neosynthesis in adults is absent. This is explained by the degree of methylation of the gene. Thus modulation of the methylation status would influence the structure — function of elastic fibers and the appearance of DT2. The first cause of DT2 is food. Thus, the simple parenting regime may predispose the offspring to develop a DT2. This assumes that a maternal prodiabetic diet could modulate the vascular methylation status of the offspring and alter the synthesis of elastin. This project proposes to study in offspring of animals fed with a pro-diabetic or non-diabetic diet: 1- methylome and transcriptome involved in elastogenesis and elastolysis 2- Post-translational modifications of elastic fibres 3- the correlation between fibre integrity and the appearance of DT2. We will demonstrate the role of a maternal pro-diabetic diet on the integrity of elastic fibers, contributing factors of DT2 and associated complications