The scientific project PFS BIO is developing the automatic and rapid acquisition of thousands of fields of view containing 100 genomic equivalents of individual combed DNA molecules. The objective is to be able to image in multi-fluorescence large samples of several centimetres in length automatically without loss of focus and at high resolution. The PFS BIO project is supported by the Montpellier DNA Combing (MDC) platform of the CNRS Montpellier — Laboratoire UMR 5535. This platform is a molecular DNA combing platform for the analysis on individual molecules of eukaryotic chromosomes. It is unique in the academic world and attracts national and international researchers. Molecular combing makes it possible to stretch and align long DNA fibers uniformly with silanised slats. These fibres can then be analysed by fluorescence microscopy (FISH, immunofluorescence). The MDC platform will work — in partnership with Montpellier Resources Imageries (MRI) — cotutelle CNRS de Montpellier. This platform has expertise and expertise in photonic imaging and image software. — And in partnership with a regional SME: Innopsys SA These two platforms have identified common technological locks, high-resolution multi-fluorescence photonic imaging on large biological samples, without chromatic distortion or loss of focus.