This partnership project is presented under the ERDF OP’s call for collaborative research projects 2014-2020, tranche 1. Jointly carried out by UMR 1134, Inserm/University of the West Indies and the AU GTSI (EA 2432), this project has been highly scientifically evaluated. It deals with sickle cell disease, a subject selected for S3. The approach to a better understanding of the vaso-occlusion phenomenon uses Atomic Force microscopy to determine the forces underlying this phenomenon and to estimate the energy barriers involved. Drépa Force aims to bring new light to the phenomenon of vaso occlusion. This data should be used to identify the receptors to be targeted as part of a therapeutic treatment. The work should help to clarify the mode of action of hydroxyurea, the only medicine used to date.