The MIS-HS-HR (Mesure In Situ High Sensitivity and High Resolution) project is part of the development of in situ analyses with very high sensitivity by ion microwave. The research carried out in recent years has shown that these in situ analyses, whether carried out on meteorites, refractory minerals or glass inclusions, are an indispensable tool for understanding the early stages of evolution of the solar system, dating to the establishment of metalliferous deposits or studying the functioning of volcanic systems.