Heart failure (CI), responsible for high mortality and frequent hospitalisations (1st cause in elderly subjects) is expensive. Purpose of this project: risk characterisation of IC by identification of combinations of biological, protein and RNA markers. It is co-financed by the RHU Fight-HF, one of the 4 hospital-university research programmes selected by an international jury, during the 1st RHU Call for Tenders for Investments of Future, PIA2. Our request is to complete the analyses on the Stanislas Cohort planned in the Fight-HF program, this will enhance the added value of this Cohort managed by the CHRU Nancy. It is exceptional for its characteristics (family, regional, 20 years of follow-up, cardiovascular phenotyping). Our goal is to include for each participant in-depth analyses of the RNAs contained in the collected blood samples, RNAs that may be biomarkers. For example, multiple analyses carried out on the cohort, including the analysis of recently selected protein biomarkers for ERDF funding, should allow the development of efficient methods for detecting early forms of IC. This will systematically identify subjects with early CI, profil them according to their risk and the mechanisms involved and in a personalised medicine approach, adapt therapies to stabilise CI at an early stage