Neurological brain lesions are observed not only in patients with severe brain trauma, but also in patients with cardiosurgery or eye diseases. Cerebral circulatory autoregulation (CTA) is one of the essential physiological factors whose disorders affect not only neurosurgery (brain injury, haemorrhagic strokes, etc.) or cardiosurgery patients, but are also associated with neurodegenic glaucoma. During cardiosurgical surgery with artificial blood circulation, a large number of surgical patients suffer from impaired brain function due to SKAR disorders. Neurological postoperative complications such as cognitive dysfunction and delirium are observed in about 53-83 % of post-hospital cardiosurgical patients and up to 42 % of patients even 5 years after surgery. The treatment of post-traumatic and postoperative (neeurosurgery, cardiosurgical surgery, organ transplantation) neurological brain lesions costs US society billions of dollars. To address this problem, a brain neuroprotective competence centre will be developed, consisting of a team of scientists and doctors of Kaunas University of Technology, Lithuanian University of Health Sciences and Vilnius University Santara Clinics. These teams will work together to develop a patentable system of real-time brain physiological monitoring and prevention of violations of cognitive functions and R & D and clinical validation of this system. A prospective scientific clinical study will be conducted in which real-time estimates of the status of SKAR will be followed by interventional medical procedures to prevent too long SKAR disorders and reduce the risk of brain damage in patients with cardio and neurosurgery. The project will develop an innovative product — patentable neuroprotective system, allowing to reduce postoperative complications of cardio and neurosurgical patients and to select targeted treatment of patients with eye diseases