The designed Centre of Competence “Fundamental, Translating and Clinical Research in Infectious Infection and Infectious Immunology” aims to strategically respond to the European Union Directive and the UN Resolution to counter growing antibiotic resistance by ensuring a rapid and effective transfer of data from basic infection research and immune response to medical practice for the needs of individual and public health. Our ambition is to build a unique research complex for Bulgaria, in accordance with the best European and world standards and practices, with a well-defined organizational structure and the necessary critical mass of well-established and young scientists and technologists-contractors. This strategy will be achieved by significantly upgrading the existing infrastructure and implementing a package of research programs in the following areas: — precise and exhaustive definition of etiological agents in the host and in the environment; — molecular-epidemiological analysis of socially significant infections;-characterisation of drug resistance of infectious agents; —research of the role of the host’s genetic and immunological ‘background’ in the development of infectious post-confectious pathology.