The overall objective of the project is to strengthen the research potential and innovation related to the gastro-intestinal, cardiovascular and skeletal themes at the University of Szeged, the University of Pécs, the University of Debrecen and the Semmelweis University and to increase the international integration of the research topics concerned. The project is made up of sub-project 3. The activities of sub-project 1 will involve strengthening the conditions for research and development of consortium partner universities, preparing human resources and research capacities for participation in international research collaborations. Engaging and training talented students and young researchers, further learning and integrating new research methods and research management methodologies into research processes. Sub-project 2 covers activities aimed at increasing the international integration of the research areas covered by the development and strengthening participation in European research networks, programmes, Horizon 2020 projects. The conditions for accession to international projects, the acquisition of the necessary knowledge and skills, the exchange of experience and knowledge transfer activities, and the establishment and strengthening of links between national and European research organisations will be realised. Sub-project 3 includes research areas and activities as a kind of horizontal activity. Within the framework of the research project, the thematically diverse research units of 4 institutions have undertaken to achieve a single goal, on the one hand, to embrace the full range of medical research, by solving specific tasks in a translational approach, and to implement basic research activities that underpin the close cooperation between domestic and international research organisations and the possibility of joining international networks and programmes. The aim of the research is to improve the living conditions and increase the life of individuals with gastrointestinal, cardiac, vascular and skeletal musculoskeletal disorders. From molecular biological research to healing activities based on new technologies, the project aims to cover the full range of medical research. Synergies between the four medical-training universities offer an excellent opportunity, as are the basic research-clinical relationships that already exist in each institution. The various research topics are linked to the fact that ion transporters are presented with special attention in the examinations of the working groups participating in the application. Ion transporters have an extremely important role in all cells, are the cornerstones of many physiological and pathological processes. Studies on iontronsporters bring different themes and research to a higher level, thus the results and discoveries of the different work of the consortium partners can be used in other research directions. In cardiology, gastroenterology, vascular and musculoskeletal research, research will be carried out in three main directions and the individual research teams will be linked: 1) physiology and pathophysiology, 2) regeneration, 3) therapy. CARDIOLOGY: In the framework of this project, we plan animal testing of arrhythogenesis, cell death and cardiac function in healthy and chronic heart failure models, followed by translational studies, during which registers will be established with the involvement of several international clinics. GASTROENTEROLOGY: Research teams are part of a wide range of gastroenterological studies: pancreatic development in fetuses, the role of CFTR in chronic pancreatitis and treatments with TRPA1 channel antagonists, the creation and use of organoids of pancreas and intestinal biobanks for in vitro studies, physiological and pathophysiological function of esophagus epithelial cells, effects of hypoxia and gastrointestinal hormones, intestinal motility, intestinal smooth muscle inflammation, primary sclerotising cholangitis, cystic fibrosis, tissue regeration stem cells, progenitors and resident cells. VASCULAR SYSTEM: Vascular dysfunctions and their therapeutic options will be examined: increased constriction of the TRPM4 channel vessels; RAAS in vivo regulation in the pathomehanism of hypertension; phosphate ion transports, transporters in vascular remodeling; the role of piezo channels in calcification processes; vascular diagnostics in a diabetic patient population with an increased risk of artery disease; processes leading to coronary obstruction in a translational approach. EXCERPT: The research of the working groups shall cover the following topics: musculoskeletal calcium household, regeneration with in vivo transfection, transporter transporter GLUT4 and SMTNL1, muscle metabolic role and adaptation during pregnancy, with sarcopenia or obesity, mitochondrial functions.