In the developed world, the decline in live births and the ageing of societies are leading to negative demographic changes, which are a major problem, both socially and economically. Despite the increasing effectiveness of assisted reproduction (ART) and in vitro fertilisation (IVF) methods and a more in-depth understanding of the physiological processes around childbirth, the success of assisted reproduction methods falls short of theoretically possible success. Meanwhile, the number of applicants for infertility treatments worldwide, and thus the number of assisted reproductive treatments, is increasing. Currently, nearly 3-4 % of children are born in this way, compared to all births. Only 25 % to 30 % of embryos implanted during IVF reach a successful pregnancy ending with childbirth. ART techniques led to successful pregnancy in 1995 in one quarter of embryo implants and 28 % of cases after ten years. At the moment, after another ten years, approximately 30 % of the implants end up giving birth alive. This low success rate is also used in Hungary to compensate for the practice of multiple embryo implantation, but multiple pregnancies entail increased health risks. According to this international consensus, the best solution is single embryo transfer. A more precise assessment of the expected viability of the embryo is essential in order to make single embryo transfer a viable option. The routine method uses morphological stamps to estimate the quality of embryos. The symmetry of the embryo, its division rate, the size of the blastomer, the granularity of the cell plasma are examined. However, it is common for an embryo which appears to be perfect from a morphological point of view to fail to meet its expectations. Alternatively, molecular markers and biomarkers of embryo viability are considered. In so doing, because, for ethical reasons, the embryo itself cannot be tested in the nutrient environment surrounding the embryo during its development prior to implantation. The basic principle of biomarker research is that it is not necessary to be aware of the exact explanation of the observed biological or biochemical phenomenon, a biomarker can be any molecule whose quantitative or qualitative changes have an accurate, reproducible diagnostic value. The present tender is based on our previous studies, during which we aimed to identify similar molecular biomarkers that can be detected from breeding fluids. In this research, we identified a fraction of the human haptoglobin protein using a mass spectrometry associated with liquid chromatography and successfully filtered morphologically undamaged but non-viable embryos in a blind, retrospective study. Besides all of this, the disadvantage of our method is that it requires the presence of an expensive and complex instrument (LC-MS), which requires additional auxiliaries to operate. This is possible in a research laboratory, but is in no way compatible with the time course of the clinical routine (mass spectrometry measurements cannot be performed routinely, reassuringly and evaluated during the time available until the embryo to be recovered into the mother). The concept of “Lab-on-a-Chip” was introduced into literature at the University of Twente, the Netherlands, in the early 1990s. LOC technology allows the integration of laboratory diagnostic procedures into a device using miniaturised microfluidical solutions. With the development of the electronics industry, a wide variety of chip methods have emerged, based on the use of silicon. In Lab-on-a-Chip systems, microtechnologies allow the integration of sample management and detection functions in square centimetres of chip size. The basic units of these microsystems are microfluidical systems, which can perform specific fluid manipulation tasks, such as flow-based separation of the liquids to be tested, biological samples, which can be broken down into the components of the sample and analysed separately. Microfluidics (microfluidics) have many advantages over classical laboratory methods. In channels with small (approximately 100 µm) characteristic dimensions, the flow is typically laminar (the “Reynolds number” in a microchannel is very low), which is a prerequisite for a constant flow in the channel, which is, by definition, an essential condition for accurate quantification. In such microchannels or even narrower nanochannels, large concentration differences can be achieved at very short distances under laminar flow conditions, allowing not only qualitative but also quantitative determinations in very small volumes. Another small advantage of micro-flow chips is the minimum reagent demand. Small size allows some nanoliter volume sample or even