Our project delivers unique and niche goals in Hungary and Central-East Europe. Among the serious acute life-threatening conditions, many of the illnesses, despite a sufficiently rapid medical intervention, have an unacceptable high mortality rate of 30-50 %. Effective research in these diseases can only be achieved by bringing together basic researchers and clinicians, i.e. through translational medicine. In this consortium, we have set a target in three main areas: Serious necrotising pancreatic inflammation, II) research in cerebral vascular disasters, and III) coordination of research on heart failure by establishing a centre(s), network(s) at international level. Given that acute cell death is common to these diseases, it is more than likely that the translating pathways identified in each area may also improve the distressing severity and mortality indicators in the diseases outlined in the project. In January 2016, the Translation Medicina Centre (TMK) http://www.tm-pte.org/ was established at the University of Pécs for the first time in Central and Eastern Europe, the main objective of which, together with the Hungarian and international centres of excellence, is to achieve serious international results in the above diseases. As a result of the application, not only will we be able to improve the severity and mortality of diseases, but our cost-effectiveness will be improved, new therapies will be introduced into everyday practice. In particular, in the field of basic research, intervention and clinical trials, IV) CORE facilities are also created, thus creating a unique R & D Strategic Workshop, which can lead to the development of high-quality research results that are internationally listed in the long term. The planned research is based on the joint, coordinated work of experts in different fields. One of the major challenges of medicine is the separation of theoretical (e.g. physiology, molecular biology) and clinical sciences (e.g. internal medicine, surgery). In many cases, the two areas no longer understand each other. Despite billions of dollars being spent on theoretical and pharmaceutical research worldwide, the number of products/medicines that can be used in patient care has not increased. Translational medicine was institutionalised for the first time in the last decade at the NIH (the world’s largest research centre with Nobel Prize-winning researchers) and Harvard University. The task of the field of science is to coordinate the different fields of research (informatics, theoretical and clinical research, biostatistics, etc.) to support research in the various medical fields in an operational manner. Linking the excellence of the theoretical and clinical knowledge base in the three areas with serious mortality will significantly stimulate the strengthening of the critical mass of high-quality R & D capacities. Sub-topic I: Based on our basic research results of severe necrotising pancreatic inflammation I.A., the MTE-MTA Multidisciplinary Gastroenterology Research Group confirmed that the intake of ATP into cells significantly reduced cell damage, which raises the possibility of energy replacement. Fundamental research specific topics: I.A1 Cellular examination of mitochondrial damage induced by the most common pancreatitis inducers (alcohol, fatty acid, bile acid) (SZTE-Rakonczay-Maléth working group (mcs)). I.A2 Developing new innovative energy-input pharmaceutical processes (PTE-Local and SZTE-Rakonczay-Maléth mcs). I.A3 In vivo testing of analgesic/anti-inflammatory compounds with various mechanisms of action in AP models (PTE-Local and SZTE-Rakonczay mcs). I.A4 Cell Death Routes were investigated in AP. (De-Flower, SZTE-Maléth mcs). I.B) The intake of energy from KLINIKAI at the PTE Translation Medicine Center in the first three months of 2016 on the early nasogastric probe significantly reduced the number of serious cases and premature deaths. However, late death was not affected. The latter can only be achieved through the development of intervention endoscopic interventions (endoscopic necroctomy). Clinical trials are conducted by the Clinical Gastroenterology Units of the PTE-SZTE-DTE. I.B1 We are currently conducting four registered clinical trials (EASY, APPLE, Pineapple, PREPAST) which are still ongoing. Organisation of I.B2 NM-RCT to compare the translational Intervention minimally invasive endoscopic procedure against current radiological and surgical intervention treatment (PTE-Vincze mcs — patients with PTE-SZTE-DTE necrotising AP will be treated in the PTE Intervention Transmission Endoscopy Center (itek) to be developed during the application) I.B3 The implementation of clinical trials of other results (pain relief, etc.) of the basic research. II. Sub-topic 1.2: Stroke The stroke is the 3 rd driver’s death