The aim of the ERDF 2018 valorisation project is to develop a working prototype of an innovative tool that can continuously monitor the functioning of the kidneys for 7 days. For the Intensive Care of the UMCG, important benefits are associated with measuring both urine production and concentration of creatinine, potassium and sodium in urine over a long period of time. For example, after major operations, the functioning of the kidneys can be monitored and, if necessary, further kidney damage can be prevented. There are currently no clinically usable techniques to measure the function of the kidneys directly. With the new diagnostic tool, early kidney damage can be detected which can prevent worse. As about a third of Intensive Care patients who stay longer than 24 hours on the IC have acute renal failure, both the health benefit and the cost benefit can be significant. It is also important that the new device will not impose any additional burden on the patient.The kidneys are vulnerable organs. Even short-term kidney damage causes an increased risk of mortality in patients both short and long term. Elderly people are particularly prone to kidney damage. Unlike some other organs, the ability of the kidneys to repair damage is very limited. Unfortunately, kidney damage is generally detected relatively late and often only if there has been a significant deterioration in creatinine clearance (an indicator of renal function). In short, the timely detection of any kind of incipient kidney damage is of great value to prevent worse. There are currently no techniques and/or medical devices that allow real-time and continuous monitoring of the function of the kidneys for acute renal failure (acute kidney injury: AKI). Starting kidney damage as well as starting acute changes in the body will have effects on acidity (pH) and concentrations of sodium, potassium and creatinine in the urine. The cooperation partners believe that some of the complications and associated kidney damage can be prevented if recognised in time by innovative non-invasive or low-invasive equipment. The main objective of this project will be achieved by implementing the three work packages in this project. The aim of work package 1 is to develop a prototype of a microfluidic flow-through device allowing the application of a final product to the ICU. The result of work package 2 is the development of the (bio)sensors to measure the relevant biomarkers in the urine. Finally, work package 3 will result in the development of an integrated prototype for real-time and continuous monitoring of kidney function. The development work in this project is expected to result in a complete new class of biomarker monitoring equipment after the end of this project. In addition to the applications in the medical world, the result of this project can also be translated into monitoring biomarkers outside the medical world, such as sports, industry and water purification.