Colon cancer or colorectal cancer is the third most diagnosed cancer in men and the second cancer in women worldwide. In 2018, there were 1.8 million new cases and 700,000 deaths worldwide. For the treatment of bowel cancer, patients undergo intestinal surgery in which a piece of bowel is removed and a new connection between the two parts of the intestine (anastomosis) is created. A common problem after intestinal tumour (intestinal cancer) operations is seam leakage. The incidence of seam leakage in colorectal operations is on average 10 %, depending on the level of anastomosis. Every year, almost 500,000 colorectal operations take place in Europe and the US, with seam leakage in almost 50,000 cases with an estimated cost for the global healthcare sector of EUR 1,875 billion. In almost 6500 (12.9 %) of patients, seam leakage due to anastomosis is ultimately fatal. The general consensus is that the degree of microcirculation (bleeding) in the tissue around the site of the anastomosis is crucial for the healing of the wound, the adhesion between the two parts of the intestine and the development of seam leakages. Good blood flow ensures a consistent supply of excipients and waste disposal, which improves the body’s self-healing ability and reduces the risk of seam leakage. Current intra-operative methodology for choosing an optimal location for anastomosis relies on a set of subjective clinical indicators focused on intestinal vitality (e.g. color or local bleeding), however, these do not guarantee proper blood flow. This project focuses on the development and clinical validation of Lapvas-Imaging, a surgical tool to visualise the blood flow of the intestinal wall during laparoscopic procedures to reduce seam leakages of sutures after intestinal surgery (approx. 10 %). This prevents associated serious complications and, in some cases, the death of the patient, resulting in a potential cost saving of >EUR 600 million for global healthcare on an annual basis. The valorisation of Lapvas-Imaging provides the North Netherlands with six additional jobs during the project and eight additional jobs after successful completion.