Separating mixtures of substances into components, fractions and phases is an essential part of our economy. Classical separations, such as extraction, distillation, absorption, crystallisation and membranes are often robust, have a proven track record and are widely applied. Disadvantages of these processes are that they are often very energy and capital intensive and cannot be achieved all the desired fractionations with these technologies. For these reasons, much research is still being carried out on new separation technologies that are more sustainable and also offer new possibilities for separation into unique components.The so-called Buoyant Density Separation (BDS) is a technology in which in an inert solvent, preferably in aqueous environment, separation is achieved by differences in the density of particulate mixtures. By setting the density of a solvent in such a way that it lies between the density of the components to be separated, the lighter component will float (float) and sink the heavier component (sink). Furthermore, by reducing the density of the solvent dosed, the lighter, floating or heavier fraction can be separated and, if desired, several fractions with different densities (= components) can be isolated. A consortium consisting of the companies Sanovations, Syncom, AVEBE, Nedmag, Hempflax, KNN and the knowledge institutions RUG and Hanze University of Applied Sciences will deepen, explore and eventually unlock the knowledge for the Northern business/region. Applications are being sought in the bioeconomy and pharmaceutical industry. The project develops an energy-efficient, sustainable, scalable and non-destructive separation technology, contributing to the desired biobased and circular transition, as well as the climate objectives set. Low-grade raw material (and residual) streams are, where possible, separated into high-quality fractions using the BDS technique for numerous commercial applications. The solvents used, preferably aqueous, are recycled and prepared for reuse. For propositions in the pharmaceutical industry, both energy needs and the amount of waste/waste formed are also reduced and the technology also offers the possibility to synthesise and/or develop existing medicines in a better way. The project contributes to the RIS3 objectives of health, food and sustainability. The knowledge and skills developed should result in a significant strengthening of Northern business. In addition to strengthening the competitiveness of the companies involved in the proposal, the knowledge and skills should also be opened up to suppliers of raw materials (agro raw materials) and those interested in the fractions to be obtained from these raw materials (cross sectoral chains), preferably from the North. The knowledge gained, also from the knowledge institutions, must result in the preservation and strengthening of human capital for our region.