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project info
Start date: 21 April 2020
End date: n/a
Project website: link
funding
Fund: European Regional Development Fund (ERDF)
Total budget: 361 017,57 €
EU contribution: 180 508,78 € (50%)
programme
Programming period: 2014-2021
Managing authority: Direzione Generale "Ricerca, Innovazione, Università, Export, Internazionalizzazione" - Unità Organizzativa "Autorità di Gestione POR FESR 2014-2020"

IMPACT OF COVID-19 INFECTION IN CHRONIC RHEUMATIC DISEASES TREATED WITH IMMUNOSUPPRESSANT DRUGS

THE COVID-19 PANDEMIC IS PUTTING GREAT PRESSURE ON THE NHS. THE HUGE TURNOUT OF UK PATIENTS TO THE LACK OF SPECIFIC SARS-COV-2 THERAPIES LEADS TO A CONSIDERABLE MANAGEMENT OF HOSPITALISED PATIENTS. DUE TO THE NEED FOR EFFECTIVE THERAPIES AGAINST COVID-19, THE REALLOCATION OF DRUGS ALREADY USED IN THE CLINIC IS HIGHLY AUSPICABLE.THE HYPOTHESIS BEHIND THE PROJECT IS THAT IMMUNOSUPPRESSIVE THERAPIES CAN MITIGATE THE RELEASE SYNDROME CITOCHINICO AND THE HYPER-ACTIVATION OF THE IMMUNE SYSTEM RESPONSIBLE FOR TISSUE DAMAGE THAT CAUSES SEVERE FORMS OF COVID-19. PATIENTS WITH AUTOIMMUNE RHEUMATIC DISEASES, IN PARTICULAR PATIENTS WITH CHRONIC ARTHRITIS SUCH AS RHEUMATOID ARTHRITIS (AR) AND SERONEGATIVE SPONDYLOARTHRITIS (SPA) ARE A MAJOR PROBLEM DURING THE CURRENT PANDEMIC. IN FACT, THEY HAVE AN AVERAGE TO HIGH DEGREE OF DISABILITY, PRESENT COMORBIDITIES IN MORE THAN 60 % OF CASES AND REQUIRE IMMUNOSUPPRESSIVE TREATMENT.

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