IN THE CONTEXT OF THE GLOBAL HEALTH EMERGENCY CAUSED BY THE COVID-19 PANDEMIC, THE PROJECT AIMS TO PROVIDE A DETAILED PICTURE OF THE PROTECTIVE IMMUNE RESPONSE AGAINST INFECTION CAUSED BY SARS-COV-2, BY ANALYSING B LYMPHOCYTE RESPONSE IN PAUCISINTOMATIC COVID-19 PATIENTS AND WITH SEVERE SYMPTOMS. THE PROJECT RESPONDS TO THE PAUCITÃ OF SPECIFIC IMMUNOLOGICAL KNOWLEDGE ON SARS-COV-2 AND THE NEED FOR TOOLS THAT SUPPORT EMERGENCY MANAGEMENT. IN SUMMARY, THE PROJECT WILL TAKE CARE OF: — EXAMINE THE GENETIC VARIABILITY OF THE VIRUS IN THE STUDY POPULATION;- STUDY WITH HIGH RESOLUTION TECHNOLOGIES THE IMMUNE AND ANTIBODY RESPONSE TO SARS-COV-2;- DETECT AND QUANTIFY VIRAL ANTIGENS IN PERIPHERAL BLOOD AND SALIVA;- DEVELOP AN IMMUNO-DIAGNOSTIC ASSAY CAPABLE OF DETECTING THE PRESENCE OF ANTIBODIES AND VIRALI ANTIGENS AT THE SAME TIME.THE CO-IMMUNITY PROJECT WILL THEREFORE LEAD TO AN ADVANCE IN OUR KNOWLEDGE OF PATHOLOGISTS.