To pursue the Smart Sustainable Green Growth is a way to recognize that citizen welfare lies on economic growth and sustainability of urban areas. The project has its primary objective in improving the innovation capacity of MED cities by creating innovation ecosystems, which involve actors of the quadruple helix (Citizens, Businesses Operators, Research, Universities and Public Authorities) , and in applying the Smart City concept, which utilizes digital and energy saving technologies to allow better services for the citizen with less impact on the environment, producing furthermore new employability and living scenarios. To achieve this goal, the project envisages the pilot testing of the Smart City concept to provide specific services to citizens in the field of intelligent urban districts, energy efficiency of buildings and smarter public lighting. The pillars on which the project lies are; (i) enhancement of existing innovative clusters and reinforcement of international networking of different relevant quadruple helix actors; (ii) mobilization of cities to change the way they operate and transact with the citizen by incorporating technology to their services; (iii) proactive involvement of local communities (Citizens and local Public Authorities) in creating innovation ecosystems. A networking approach will be used to transfer the project results (in the form of Innovation Policy Change Recommendations) to Public Authorities in the MED area.