Our cross-border regions are subject to inequalities in terms of healthcare and there is an increase in certain diseases such as bronchopulmonary cancers, while early detection makes it possible to increase recovery rates from 15% to 80%. To facilitate access for all populations on both sides of the border, PATHACOV is developing a new range of screening care services. A simple, non-invasive and inexpensive technique is being developed to detect cancer early by analysing volatile compounds in the breath of populations. Five hospitals and six research laboratories are working together to develop a prototype sensor to detect the risk of cancer in the cross-border population at an early stage. The challenge taken up by this project is based on specific and complementary skills on both sides of the border. The added value is to develop a common culture through exchanges of good practices, innovative methods and end products that benefit cross-border populations and territorial policies. In order to raise awareness and develop this early screening, realistic scenarios and broad communication on the project are carried out in collaboration with local political and occupational health authorities, patient associations and all health stakeholders at grassroots level.