The four EU macro-regional strategies (EUSBSR, EUSDR, EUSAIR and EUSALP) provide an integrated framework to address common challenges for the Member States and third countries located in the respective geographical areas. The strengthened cooperation is expected to benefit the economic, social and territorial cohesion. This service contract is focused on: (1) the Adriatic and Ionian Region and (2) the Danube Region. In both macro-regions disparities and diversities within and between their member countries (the EU member states, the EIU candidate countries and EU neighbour countries); present clear challenges to achieving goals of the Strategies. The EU Strategy for the Adriatic and Ionian Region (EUSAIR) partially overlaps with the EU Strategy for the Danube Region (EUSDR), which was established a few years earlier. This inequality in maturity of governance structure and stock of analyses can potentially play an important role in exploiting synergies between the two macro-regions in light of the pursued goals of a better territorial integration and cohesion in a wider geographical area than just one specific macro-region. The objective of this activity is to develop territorial scenarios for the EUSDR and EUSAIR as the means to enhance the territorial dimension of the respective EU Strategies and to embed the territorial evidence in policymaking at relevant levels of the countries involved in their implementation.