High performance computing (HPC) is an emerging general-purpose technology. It can improve framework conditions for innovations by drastically increasing effectiveness of innovations and reducing product development time. However, while most advanced HPC infrastructure and knowledge are located in well-off western parts of the Danube region, enterprises – especially SMEs – from its eastern parts have limited access and competencies. Transnational cooperation in the region is limited, which is further hindering innovation. The main objective of InnoHPC is to create transnational HPC laboratory for co-designing knowledge-intensive innovative products with high value-added in transnational value-chains. Key outputs are transnational InnoHPC Lab pooling regional HPC infrastructure and competencies, web platform providing HPC access, integrated services and capacity building tools, and sustainability toolkit, to support durability of InnoHPC Lab beyond the project. To achieve them, InnoHPC will, first, conduct a focused regional HPC benchmark, second, design and create a transnational InnoHPC Lab, third, develop HPC web platform providing HPC access and capacity-building tools and finally, pilot-test InnoHPC Lab and the platform with two pilots with SMEs in electronic and automotive sectors. InnoHPC targets SMEs and clusters, providing the opportunity to increase efficiency of innovations and join transnational value-chains in the Danube region. Higher education and research institutions with HPC will get access to exciting real-life cases and opportunities to exploit their entrepreneurial potential. Policy-makers and business support organizations will receive a valuable institutional support for their policies and initiatives. InnoHPC project is a pioneering effort to improve framework conditions for innovation by providing unique institutional and technological infrastructure, designed specifically to pool and exploit HPC infrastructure on a transnational level.