Integration of regional/local policies for Sustainable Mobility, Accessibility & low-carbon Responsible Travel, with policies for efficient sustainable tourism towards a low-carbon economy, requires particular attention in the EU. This is a common challenge that public regional/local and transport authorities increasingly face, particularly at busy destinations with high tourism travel flows (inc. in South Europe, coastal, maritime & insular, mass tourism destinations). Immediate action is needed through interregional cooperation to capitalise best practices, improve policy instruments & prepare action plans with implementation monitoring & evaluation. The DESTI-SMART project, addresses the above towards 'Smart Destinations', for sustainable & responsible tourism development in Europe, with low-carbon, multimodal sustainable mobility & accessibility. The overall objective is to improve the transport and tourism policies of EU destinations, by integrating strategies for sustainable mobility, accessibility and responsible travel with efficient & sustainable tourism development, for transition to a low-carbon economy, through efficiency, resilience, multimodality, novel low-carbon transport systems, cycling & walking, with implementation innovations, policy learning and capacity building. The following pressing issues are addressed: - Investments in low-carbon transport systems for mode shift to sustainable tourism mobility, incl. Electro-Mobility. - Intermodality facilities for visitors, including ICT, Mobile Aps & MaaS. - Accessible tourism for all. - Cycling & Walking facilities & promotion for visitors. Main outputs: - policy learning & capacity building for public authorities & their stakeholders. - improved policy instruments & action plans in 9 destinations, with close involvement of stakeholders. - advances in EU2020 objectives. - communication & dissemination learning materials. - network of public authorities towards low-carbon S.M.A.R.T. destinations in Europe.