New models of innovation are needed because globalization and digitalization cause rapidly changing value chains and business models. Policy makers need to learn about such new models to keep the pace and be able to provide fast and flexible support for emerging industries in order to make/keep a region competitive at global scale. ClusteriX 2.0 aims to improve policy instruments related to the actual delivery of innovation making better use of clusters to facilitate such processes by focusing on complementary competences, by introducing new models of innovation for the development and operational implementation of strategic cluster partnerships. Our goal is to increase the number of collaborations between enterprises and knowledge institutions (by 5 % on average by 2020) leading to new value chains through cross-cluster collaboration and eventually to new products and solutions. This shall be done by improving policy instruments related to networking, clusters and open innovation through smart specialization. As sub-objectives we intend to increase the number of cross-sector collaborations and cluster partnerships within each partner region and to develop strategic interregional partnerships based on complementary competences identified through smart regional profiling. The main outputs are 81 policy learning events organized, minimum 20 good practices identified, analysed and shared, 10 action plans developed and implemented and minimum 50 appearances in media. Direct beneficiaries are at least 50 people from Managing Authorities/Intermediate Bodies, implementing organizations, and various local/regional/national stakeholders with increased professional capacity benefiting from the interregional exchange. Through improved policy instruments (9 Structural Funds, 1 regional) enterprises, research institutes and other innovation actors in the region benefit indirectly from ClusteriX 2.0.