OIS–AIR establishes and develops the Open Innovation System of the Adriatic-Ionian Region: a Hub&Spoke network forging lasting transnational links and leveraging the raw materials of the 21st century, knowledge and innovation. The Hub, coordinated by AREA Science Park, connects the Innovation Centres-Spokes-disseminated across the Region: local assets and excellences-research infrastructures, incubators and accelerators, specialisations, human capital-are pooled together to create a critical mass, crucial to meet the tech&inno needs of SMEs and generate societal growth. OIS-AIR approaches the transnational cooperation on innovation from a multi-level perspective: strategic planning and policy commitment; skills development; design of tailored tools, methodologies & services; deployment of pilot industry-research collaboration schemes. OIS-AIR unlocks the innovation potential of the Region as a whole: it designs a Pilot Adriatic-Ionian S3 aimed at building initiatives on synergic specialisation sectors and KETs and it develops an Action Plan for the Pilot Adricatic-Ionian S3 implementation and monitoring. OIS-AIR is rooted to the ground and fed in a virtual space: OISAIR is a formal Hub&Spoke netwok of innovation support organisational and physical facilities open to research and companies; OISAIR Hub is a virtual environment for the coordination and operations of the OISAIR network, a web-based portal, an area for knowledge, innovation, technology, initiatives and opportunities exchange developed and fed by its users and beneficiaries. OISAIR network is the gateway to the best tech transfer & innovation support services in the Region: it opens the doors of the best innovation and research facilities to SMEs, start-ups & spin-offs. OISAIR walks one step before innovations uptake: it shares knowledge and anticipates technologies, incubates the best ideas and accelerates the valuable ones, develops and tests research valorisation schemes. OISAIR pushes research based innovation in SMEs: a tailored Proof of Concept scheme is designed and vouchers are delivered to the 10 most promising co-development projects (research-driven transnational innovation projects) embedded into the pilot Adriatic-Ionian S3. OISAIR is the single marketplace for technology and innovation: be competitive regionally and globally, stay tuned OIS-on-AIR!