INKREASE - Innovation and Knowledge for Regional Actions and Systems - aims at improving innovation delivery capacity of participating regions: the main goal is to mainstream, into the different regional strategies of partners, policies and tools to increase the capacities of the various innovation ecosystems, reinforce the collaboration between research and business communities and exploit the economic valorization processes of research results. INKREASE learning process tackles aspects related to: - management of structured innovation networks and clusters; - appropriate tools and mechanisms to leverage business investments in research and innovation; - new and more effective governance models; - sector specific needs. INKREASE has a clear focus on the challenges emerging from RIS3 and the identification and development of new value chains to support research-enterprise cooperation. Good practices on governance models, industry-science relations management schemes, business clustering and networking experiences are taken as inspiration for the regional Action Plans. The partnership covers 7 areas across the EU with similar RIS3 priorities and ERDF policy instruments, and includes Regional Authorities, innovation agencies and business support centers. Local Stakeholder Groups will act as keystone between regional priorities and interregional competences to be mainstreamed. Policy makers, representatives of research and business communities and other actors promoting and delivering innovation services are involved in the learning exercise, providing inputs and taking advantage of projects results. Project activities lead to the definition of 7 Action plans aimed at improving regional policy instruments with new actions, tools and governance mechanisms, increasing production and capitalization of results, mainly in terms of number of companies collaborating with research institutions and amount of private investment on research and innovation.