The 3dBio project, co-built with challenge 3 of CAP 20-25 is part of the EPICURE challenge. One of the peculiarities of biological systems is their ability to organise in 3 dimensions and to respond to the related constraints. The 3dBio project aims to explore recent technological advances that allow either to structure matter in 3D to reconstruct an environment similar to that of the actual biological situation or to modify its properties by 3D structuring, or to reproduce a physiological situation where cells see a 3D flow and mechanical stress causing them to organise themselves in a specific way. The project is divided into 3 complementary components based on strong expertise of the implicated laboratories: Component 1 – 3D printing of bioceramics for bone substitutes and/or supports for bone tissue engineering; Component 2 – 3D printing of protein foods to supplement a deficient masticatory function; Component 3 – Studies of cells subjected to controlled flux mimicring a biological context and their 3D spatial organisation.