Multiparametric recognition of label-free biomarkers in real time associated with kinetic data is a paradigm of modern in vitro diagnostics. Nowadays, two types of label-free optical sensors have been described, one based on surface plasmonic resonance (SPR) in metal island films and the other using surface waves (SW) in photonic crystals (PCs). However, the “genetic” weakness of SPR techniques is the rapid decay of the signal during propagation on a metal film which limits the sensitivity of SPR-based sensors. Contrary to the SPR principle, biosensors using SW PCs ensure long-range surface wave propagation and higher sensitivity than SPR media. At present, no 2D imaging approach based on PC sensors has been proposed. The FreeBioWave project will develop an imaging modification of SW PC sensors to detect and measure up to 2,000 reactions simultaneously on the surface of a biochip. Last but not least, the FreeBioWave project responds perfectly to the research questions covered by the research theme – Technologies for Health – which includes, as main directions, biosensing and instrumentation for surveillance.