Knowledge of the structure of biological macromolecules or viruses is an essential issue for the development of new drugs and the fight against pandemics, as has unfortunately been shown recently. Transmission electron microscopy (MET) has now become an essential technique in this field through electron cryomicroscopy (cryo-MET).The objective of the REACT-EU project “occit EM” aims to equip two transmission electron microscopes from two Toulouse laboratories, CEMES-CNRS and CBI-UT3-CNRS, ultra-fast and ultra-sensitive direct electron detection (DDE) cameras so that researchers can develop their work in structural biology at their best level. — The DDE camera installed at the CBI will allow the actors of the Toulouse research cluster in biology and health and more broadly of the national community to have access to the latest generation equipment in cryoMET to develop their work in the fields of health. — The DDE camera installed at CEMES will allow the development of an innovative method of studying biological objects by electronic cryo-holography. This original method of which the CEMES team is a leader must make it possible to propose an alternative to certain limitations related to conventional methods of cryo-MET studies.