Infectious diseases remain a major cause of global mortality and represent a significant economic and societal cost. On the other hand, recent research on microbiota has highlighted their essential roles in multiple facets of mammalian physiology. Disruption of the function or composition of these sets of microorganisms is often associated and sometimes causal to the development or worsening of chronic pathologies such as inflammatory bowel diseases, diabetes, obesity or cancer, but also to resistance or sensitivity to certain infectious pathologies. The study of these models requires access to confined laboratories allowing standardised and controlled experimentation that protects both the experimenter from manipulated pathogens and preserves the microbiological status of the models studied, thus maximising their biological and experimental relevance. This project will increase the service offer for academic and industrial research projects necessary for the development of knowledge and its therapeutic applications.