Federated by imaging, ICube has as preferred fields of application engineering for health, the environment and sustainable development. Its interface with the medical world is exceptional thanks to the establishment of three of its teams on the site of the University Hospitals of Strasbourg (HUS), its partnership with the IHU of Strasbourg (mini-invasive surgery guided by the image) and IRCAD as well as its active participation in the Federation of Translational Medicine of Strasbourg (FMTS). ICube’s experimental means are organised into 6 shared platforms attached to the management of the laboratory, including the innovative health imaging platform “Imagines”. The project aims to provide in-vivo imaging equipment (preclinical) for the “Imagines” platform, which is essential for the development of translational research in the life and health sciences on the Strasbourg site with innovative equipment and original information processing tools. The project plans to establish a coherent and integrated infrastructure of small animal imaging facilities open to the academic, clinical and biomedical and biopharmaceuticals community.