Infectious diseases pose a significant health risk. Modern bioinformatics based on high-throughput data offer new possibilities for the detection of biomarkers. PiDOMICS develops methods for the automatic preprocessing of high-throughput data and the detection of biomarkers for (i) estimation of individual infection risk, (ii) improved diagnosis and (iii) support for treatment decisions. These procedures are established using the example of invasive fungal infections and use already existing and newly obtained data.