For the TRI-IPBS platform, the challenge is to deal with the obsolescence of equipment that has enabled major discoveries. Their renewal will allow to benefit from the latest technical developments in particular at the level of detectors which have become faster, sensitive and resolute, allowing to preserve the samples by reducing the illumination while increasing the resolution of the images, thus offering the prospect of new discoveries. Co-financing has already been obtained to replace the so-called "right" microscope and PRIO funding will allow the replacement of the so-called "reverse" part. The LITC-CBI currently has a confocal microscope with a saturated rotating disk that requires rejuvenation to meet current challenges. The planned developments will provide access to wide-field and ultra-fast imaging on large samples, adapted to animal models or organoids. The coupling with a high resolution screening system using microfluidics is quite innovative and allows the observation of hundreds of samples per day with the characterization of several zones.