The Leiden Bio Science Park is the largest campus in South Holland and belongs to the top three National Top Campuses and is one of the largest innovation clusters in the Dutch economy. The LBSP has a unique triple helix governance: local authorities, knowledge institutions and companies contribute administratively to the cohesion of the park. The cluster has a high impact on the economy and on innovations in health and care. In order to ensure a healthy growth of the LBSP and the application of innovations in healthcare in the future, it is important to provide low-threshold support to start-ups and SMEs. The early phase of innovation development is promoted through a contribution to establishment costs and through support with services to accelerate growth and innovations of SMEs and start-ups. The LBSP acts as a bundle applicant and provides vouchers to SMEs through a balanced procedure to strengthen the LBSP ecosystem and accelerate innovation.