Osteoarthritis (OA) is an age-related, degenerative joint disease that leads to pain, swelling and stiffness and has a very high incidence and impact due to increasing aging. Current treatments are limited and mainly aimed at fighting pain and inflammation and/or surgical joint replacement. A healing treatment option for regenerative cartilage repair is not yet available. In this OPZuid project, an innovative new cartilage-on-a-chip model is being developed: the INTELLECTUALS chip. The consortium's chip results in an improved process for the study and development of new cost-effective, personalized OA treatments. This will make regenerative cartilage repair possible, because the effect and efficiency of treatments and medicines can be mapped out cheaply and accurately. In addition, the cells of patients can be grown on the chip to give personalized advice.