Healthcare Frontline Innovation aims to address problems that nursing organizations face related to (1) resource shortages in healthcare, (2) long-term skills supply and (3) a sustainable working life by increasing nurses' and assistant nurses' skills and participation in innovation processes. In order to achieve successful results and meet the challenges facing healthcare, nurses' and assistant nurses' competence in innovation needs to be strengthened, including how nursing organizations interact with industry, academia and patients around innovation. In addition, there is a need to strengthen surrounding support and structures in order to utilize competence development as part of daily work and achieve long-term change in the nursing organization. In a pre-study conducted with nursing managers within Theme Acute and Reparative Medicine (ARM) from Karolinska University Hospital in autumn 2022, the needs for nursing-led innovation were identified: Nurses and assistant nurses often feel that they are not heard in their organization and feel that they are not given the opportunity to influence the care given to patients. They often lack autonomy and the ability to influence their work situation, which is strongly linked to exhaustion and feelings of insecurity at work. In a survey, 81% of nursing managers said that the work environment would improve, 70% said that patient safety would increase and on average they thought that about half of nurses and assistant nurses who had left last year would have stayed at least one more year, given an increased influence in the development of care for nurses and assistant nurses. With the insights from the pre-study as a basis, a concept development phase was then carried out with additional nurses and assistant nurses, representatives from other healthcare professionals and external actors (business and academia). A framework was jointly developed that details what skills must be developed and what support and structures must be in place in the nursing organization to enable nursing-led innovation. The framework includes 6 dimensions: 1. Vision and strategy – what is the vision for care-led innovation and how should we pursue it? 2. Management and governance – how to organise effective governance of care-led innovation? 3. The innovation process – how should ideas be collected, evaluated and implemented into ready-made solutions? 4. Employees and skills – how to achieve lifelong learning, development, culture and engagement? 5. External collaboration – how should collaboration with external actors be structured? 6. Systems and technology – what digital tools and skills are needed to support the work? By starting from the dimensions of the framework, the project will train nurses and assistant nurses in innovation and thus enable nursing staff to participate in and lead innovation processes to a greater extent. If assistant nurses and nurses have greater influence over the development of health care, it can lead to two strongly female-dominated occupational groups being strengthened in the labour market, improved well-being and improved hospital results. The project will also mobilise and involve other professions and functions from Karolinska University Hospital, as well as different types of external actors, to establish structures and processes for internal and external collaboration on innovation. In this way, a more effective interaction between healthcare, industry, academia and patients is created and the knowledge and capacity available in the region can be used in the best way and contribute to a sustainable development of healthcare and a stronger life science sector. The project is owned by Tema ARM at Karolinska University Hospital, which has a nursing organization consisting of more than 1,000 nursing managers, nurses and assistant nurses. The entire hospital has over 8,000 nurses and assistant nurses. The project aims to reach 500 participants in Theme ARM and 2000 participants in other Themes and Functions at Karolinska University Hospital. Results from the project will be communicated and disseminated to other hospitals and regions through a portfolio of activities on how to achieve nursing-led innovation.