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project info
Start date: 1 October 2024
End date: 30 September 2025
funding
Fund: European Regional Development Fund (ERDF)
Total budget: 138 432,00 €
EU contribution: 138 432,00 € (100%)
programme
Programming period: 2021-2027
European Commission Topic
European Commission Topic

Innovative system for testing chemicals (in particular drugs) on human and animal cells based on microflows

Microflows are a type of technology that can replace the traditional approach to biological experiments, characterized by precise fluid flow control and high throughput. In recent years, research has shown that microfluidics are very promising in terms of improving biological testing and diagnostics. To better reflect in vivo conditions, the project involves cell culture in hydrogel-filled incubation micro-cells. Hydrogels have a physical similarity to a native extracellular matrix, which can imitate the natural environment of cell growth. The combination of a microfluidic structure with specially adapted micro-chambers together with a hydrogel with unique properties can serve as an innovative platform for studying cell populations, helping to determine their reaction to a given chemical or drug. An experienced design team will carry out a series of tests and work aimed at obtaining at least a prototype of the proposed system. Among them, it was planned to build a microcircuit based on previously conducted research, create a numerical model of the diffusion process of the tested substance, develop software and flow control, synthesis and physicochemical analysis of the thermosensitive hydrogel, conduct a series of biological experiments, comprehensive data analysis with the creation of an application and a series of activities aimed at promoting the project. The numerical model of the diffusion process of the drug under test in the medium will be used for virtual testing of the designed solutions of microfluidic systems before introducing the solution into production. The device is planned to try to use a cheap, durable and useful polymer - PMMA. The proposed microfluidic technology makes it possible to study the behavior of cells with the precise application of experimental conditions unattainable using macroscopic tools.

Flag of Poland  Gliwicki, Poland