The Czech Centre for Phenogenomics is the only centre of its kind in the Czech Republic creating and characterizing genetically modified mice and rat models important for gene research in the development and treatment of human diseases. The aim of the project is to modernize CCP by upgrading technologies in order to maintain competitiveness and expand the service portfolio. Investments in the preclinical platform and complementary technologies alternative to animal models will mitigate the impacts of the risk associated with animal models.