Antimicrobial resistance (AMR) is a global health crisis that causes millions of deaths every year and is projected to become the leading cause of death by 2050 unless preventive action is taken. Bone infections, in particular osteomyelitis (OM) and implant-associated infections, significantly increase this burden, especially with multidrug-resistant pathogens, which complicate treatment. Antibiotic-based treatment of bone infections is often ineffective due to biofilming, side effects and increasing bacterial resistance. Therefore, the RESCUE project aims to develop innovative injectable nanocomposite hydrogels with antimicrobial and osteogenic properties without the use of antibiotics. The main project activities include: 2. Research involving at least one of the following research categories: fundamental research, industrial research, experimental development. 3. Acquisition, validation and protection of technology rights (intangible assets). 4. Dissemination of knowledge generated by the project in the form of training, publications or transfer of know-how and technology. 5. Measures to ensure communication and visual identity requirements. Classification of projects according to the General Classification of Economic Activities: NACE:72.19 - Other research and experimental development in natural sciences and engineering. RESCUE's interdisciplinary R&D approach, which combines cutting-edge engineering innovations with cutting-edge medical biotechnologies, mainly corresponds to FORD code 2: Engineering and technology (including 2.5 Material engineering, 2.6 Medical engineering and 2.9 Industrial biotechnology) and FORD code 3: Medical and health sciences (in particular 3.4 Medical biotechnology). The main area of the RESCUE Research and Innovation Strategy for Smart Specialisation (RIS3) is Biomedicine, Medical Technologies and Biotechnologies. In addition, RESCUE supports the RIS3 area "Smart materials, technologies and engineering systems", thus contributing to the overall development of the Latvian economy. Focusing on the biomedical and pharmaceutical sectors, RESCUE strengthens Latvia's innovation capacity by contributing to the RIS3 goal of creating knowledge-intensive products with high added value. The project strengthens Latvia's innovation ecosystem by promoting cooperation between academic, research and industrial sectors, which is in line with the RIS3 objective of integrating Latvia into global value chains. In addition, RESCUE supports the RIS3 domain 'Smart materials, technologies and engineering systems' by creating multifunctional hydrogels from renewable natural resources, directly addressing the RIS3 focus on high-value bio- and composite materials for economic transformation. By developing smart biomaterials for regenerative medicine and antimicrobial applications, RESCUE supports Latvia's position in the field of biomedical innovation, promoting its export potential in solving critical health care issues. By promoting innovation in biomedicine, medical technologies and smart materials, RESCUE directly supports all three strands of the RIS3 transformation, transforming traditional industries, fostering future high-value-added growth sectors and ensuring horizontal economic impact through interdisciplinary collaboration and sustainable solutions. RESCUE results will contribute to economic sector growth and innovation according to NACE Rev. 2 - 32.50: Manufacture of medical and dental instruments and supplies, ensuring significant progress in this sector. At the start of the RESCUE project, the Technology Readiness Level (TRL) is defined as TRL 2, but TRL 5 is expected to be reached by the end of the project. In order to achieve the transition from TRL 2 to TRL 5, Project Action 2 is structured in 9 sub-actions focused on R&D. Under the RESCUE project, industrial research (sub-actions d1, d2, d3, d4, d5, d6, d7) will focus on the development and optimisation of injectable nanocomposite hydrogels. These hydrogels will be characterised in vitro under laboratory conditions to assess their antimicrobial, osteogenic, biocompatible and antioxidative properties by increasing the TRL from TRL 2 to TRL 4. Based on these in vitro results, the most effective composition of the nanocomposite hydrogel will be determined through experimental development (project subactions d8, d9) and tested in vivo in animal models. This assessment will confirm the biosafety and efficacy of the hydrogel for medical applications, allowing the project to achieve TRL 5. RESCUE is a non-economic cooperation project that combines multidisciplinary and cross-sectoral knowledge. The leading partner of the project (research institution) is Riga Technical University, scientific manager: Prof. Dagnija Loca (Riga Technical University (RTU - multidisciplinary technical university, the only institution of its kind in Latvia. RTU is strategically moving towards third-generation university status, offering not only high-quality ed