Advanced human pre-metastatic innervated niche engineering: the impact of extracellular vesicles of prostate cancer on the pathological neurotization of bone metastasis The innervation of prostate cancer (PCa) reflects a worse prognosis. Bone metastases exhibit disorganized sensory innervation patterns. Extracellular vesicles (EVs) play a crucial role in the spread of cancer. We propose an innovative model to understand the impact of VEs on sensory innervation of bone, preparing the microenvironment to host tumor cells. This knowledge will be vital to stop PCa metastases.share on FacebookTwitterLinkedinEmailreport an issue
