EndPFAS aims to assess the impact of exposure to PFAS (ubiquitous, persistent and toxic chemicals) in utero on cardiometabolic, hepatic and reproductive health from childhood to adulthood, in line with the European scientific agenda for chemicals. EndPFAS uses data from the Portuguese birth cohort G21 and has an international and multidisciplinary team. Its results will be very relevant to researchers, policy-makers and society.