The object of the operation is the energy upgrade of the General Hospital of Karpenisi through interventions to improve the energy efficiency of the building and installation of a RES system.In particular, the operation includes interventions for the external thermal insulation replacement of frames for the upgrade of the heating system by replacing existing boilers and burners for the upgrade of the artificial lighting system by replacing conventional lamps with corresponding LED technology.It is also provided for the installation of an automated building energy management system Building Energy Management System.Finally, the operation includes the installation of a photovoltaic system with a power of 99 kWp for the production of energy for the needs of the infrastructure by applying the netmetering energy offsetting.After the implementation of the interventions, the improvement of the energy performance of the building is expected to be classified as energy class B' according to KENAK 2017 from E', where primary energy savings of the order of 52 currently belong, the reduction of the operational cost of the infrastructure as well as of greenhouse gas emissions by 48