West Macedonia faces the demands of climate change and the transition to a new energy model with the development of technology and innovation Designs and implements in the Region that was the heart of energy the Hydrogen node that ranks it in a pioneering Region of the EU with significant benefits for Greece but also a pole of attraction for Southeastern Europe This emblematic project is being developed by CERTH in Ptolemaida with the new Branch of CERTH. The Hydrogen node is pioneering because it brings together all modern technologies, namely the production, storage and use of Hydrogen with the corresponding technological processes for the formation of energy efficient and functionally mature solutions as well as the certifications that are scientifically and operationally necessary