The aim of this project is to develop the first in class, innovative, safe and clinically effective bispecific protein format (VHH/VH, SCFV or Fab), allowing for targeting both the immune response pathway PD-1/PD-L1 and selected growth factor receptors, and its validation in Phase I and II clinical trials as a candidate for use in solid tumour therapy. Innovative candidates will be generated on the basis of Phage Display technology and immunisation to select specific fragments against selected molecular targets. The production of selected molecules will be based on mammals or bacterial expression systems. By applying a bispecific technological approach, it will be possible to simultaneously inhibit or modulate two molecular targets. Bispecific formats and similar structures are now one of the most innovative trends in the development of therapeutics. The project will be implemented in 8 stages for a period of 52 months. The first steps will include industrial work on the development, selection of effective molecules capable of interacting with relevant molecular targets. The next step will be the selection of synergistically acting pairs using available physicochemical methods, biochemical tests, in vitro and in vivo methods. The most effective pairs will be prepared in bispecific format. For selected molecules, an innovative production process with analytical methods will be developed, which will allow to obtain a charge for toxicological and clinical studies. The final stage of the project will be development work involving clinical trials. Pursuant to Article 25 of Regulation (EC) No 651/2014 of 17 June 2014 declaring certain types of aid compatible with the internal market in the application of Articles 107 and 108 of the Treaty (OJ L. I'm sorry. EU L 187/1 of 26.06.2014).