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project info
Start date: 1 July 2018
End date: 28 September 2021
funding
Fund: European Regional Development Fund (ERDF)
Total budget: 444 504,86 €
EU contribution: 444 504,86 € (100%)
programme
Programming period: 2014-2021
Managing authority: Ministerstwo obsługujące ministra właściwego ds. rozwoju regionalnego

Spatial organisation of FGF receptor 1 by multimeric ligand assemblies

Fibroblast growth factors (FGFs) and their receptors (FGFRs) transmit signals through the plasma membrane, modulating cell behavior and body homeostasis. Alterations in FGFR1 signaling trigger carcinogenesis and severe noncancerous diseases. Upon ligand-induced dimerisation two FGFR1 molecules activate each other by transphosphorylation. However, the extent and pattern of FGFR1 modification will be affected by the distribution of the neighboring receptors, thus influencing cellular outcome. In this project we will cluster FGFR1 on the plasma membrane using multimeric ligand assemblies (MLAs). By employing different FGFR1 ligands and their configurations in MLAs, the spatial requirements for FGFR1 function and receptor trafficking will be evaluated. The results obtained within this project will explain the relationship between oligomeric state of FGFR1 and its function and will constitute basis for development of novel therapeutic strategies against aberrant FGFR1 signaling.

Flag of Poland  Trójmiejski, Poland